chopshopr

Disease Hypothesis Engine

The first wedge is sickle cell disease: high suffering, public data, fast assays, measurable biomarkers, and a built-in contradiction from existing but hard-to-scale cure paths.

Outputs 1-3 Causal map, target ranking, repurposing queue.
Top targetBCL11A / HbF axis
Top candidateHydroxyurea
Outputs 4-8 Subgroups, biomarkers, protocols, and study sketch.
Subgroups
    Biomarkers
      Human-study sketch

      Receipts Public data trail and automation hook.
      Renderer hook window.render_disease_hypothesis_engine_to_text()

      Returns the selected disease, top target, top repurposing candidate, source count, and audit state.

      Source stamp 20260626-disease-hypothesis-engine

      Locks the public demo to a source-backed, testable packet instead of a chat transcript.

      Anti-hardcoding invariant weight perturbation + alternate disease selection

      Tests prove that the default answer can change when the ROI weights or disease input changes.