:root {
  color-scheme: dark;
  --ink: #0b0f0e;
  --panel: rgba(18, 24, 23, 0.92);
  --panel-2: rgba(239, 245, 224, 0.065);
  --line: rgba(238, 246, 225, 0.16);
  --paper: #eff6df;
  --paper-2: #c9d3c1;
  --muted: #879488;
  --lime: #b7ff52;
  --cyan: #58dccd;
  --coral: #ff7665;
  --amber: #ffc25c;
  --shadow: rgba(0, 0, 0, 0.42);
  --font-display: "IBM Plex Sans", "Avenir Next", "Helvetica Neue", sans-serif;
  --font-mono: "IBM Plex Mono", "SFMono-Regular", Consolas, monospace;
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  background:
    linear-gradient(120deg, rgba(88, 220, 205, 0.08), transparent 36%),
    linear-gradient(0deg, rgba(255, 118, 101, 0.07), transparent 34%),
    var(--ink);
  color: var(--paper);
  font-family: var(--font-display);
}

a {
  color: inherit;
  text-decoration: none;
}

button,
select,
input {
  font: inherit;
}

.disease-lab-shell {
  min-height: 100vh;
  padding: 18px clamp(12px, 2.5vw, 34px) 44px;
}

.source-grid a {
  border: 1px solid var(--line);
  border-radius: 6px;
  padding: 8px 10px;
  color: var(--paper-2);
  font-size: 0.78rem;
  font-weight: 850;
}

.lab-topbar[data-site-header] .site-topbar__nav { display: grid !important; flex: 1 1 auto; justify-items: end; overflow: visible; }

.lab-topbar[data-site-header] .site-secondary-links[data-disease-section-nav] {
  display: flex !important; max-width: 100%; flex-wrap: wrap; justify-content: flex-end; gap: 8px; overflow-x: auto; scrollbar-width: none;
}

.lab-topbar[data-site-header] .site-secondary-links[data-disease-section-nav]::-webkit-scrollbar { display: none; }

.lab-topbar[data-site-header] .site-secondary-links[data-disease-section-nav] a {
  min-height: 44px !important; background: rgba(8, 12, 11, 0.9) !important; color: var(--paper) !important;
}

.lab-focus-strip,
.hero-proof,
.control-grid,
.candidate-panel,
.engine-panel,
.protocol-panel,
.falsify-panel,
.source-section {
  border: 1px solid var(--line);
  border-radius: 8px;
  background:
    linear-gradient(140deg, rgba(239, 245, 224, 0.055), rgba(88, 220, 205, 0.035)),
    var(--panel);
  box-shadow: 0 24px 90px var(--shadow);
}

.lab-focus-strip {
  display: grid;
  grid-template-columns: 120px minmax(240px, 1fr) minmax(260px, 0.86fr);
  gap: 16px;
  align-items: center;
  margin: 14px 0;
  padding: 14px 16px;
}

.lab-focus-strip span,
.panel-heading span,
.mini-heading span,
.selected-brief span,
.protocol-grid span,
.study-sketch span,
.falsify-card > span,
.receipt-grid span,
.candidate-card span,
.target-row span,
.drug-card span {
  color: var(--lime);
  font-size: 0.72rem;
  font-weight: 950;
  text-transform: uppercase;
}

.lab-focus-strip strong {
  font-size: 0.98rem;
}

.lab-focus-strip p,
.hero-copy p,
.selected-brief p,
.selected-brief li,
.mechanism-node p,
.target-row p,
.target-row em,
.drug-card p,
.protocol-list p,
.protocol-list em,
.study-sketch p,
.falsify-card li,
.audit-card p,
.receipt-grid p,
.source-grid span {
  color: var(--paper-2);
  line-height: 1.48;
}

.hero-grid {
  display: grid;
  grid-template-columns: minmax(300px, 1.12fr) minmax(280px, 0.72fr);
  gap: 14px;
  align-items: stretch;
}

.hero-copy {
  display: grid;
  align-content: center;
  min-height: 220px;
}

h1,
h2,
h3,
p {
  margin-top: 0;
}

h1 {
  margin-bottom: 12px;
  max-width: 860px;
  font-size: clamp(2.3rem, 4.8vw, 4.9rem);
  line-height: 0.96;
}

.hero-copy p {
  max-width: 860px;
  margin-bottom: 0;
  font-size: clamp(1rem, 1.5vw, 1.25rem);
}

.hero-proof {
  display: grid;
  gap: 10px;
  padding: 14px;
}

.hero-proof div {
  display: grid;
  gap: 5px;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 13px;
  background: rgba(9, 13, 12, 0.58);
}

.hero-proof span {
  color: var(--cyan);
  font-size: 0.7rem;
  font-weight: 950;
  text-transform: uppercase;
}

.hero-proof strong {
  font-size: 1.08rem;
}

.control-grid {
  display: grid;
  grid-template-columns: minmax(190px, 0.8fr) repeat(4, minmax(160px, 1fr));
  gap: 10px;
  margin: 14px 0;
  padding: 12px;
}

.control-grid label {
  display: grid;
  gap: 8px;
  min-width: 0;
}

.control-grid span {
  color: var(--muted);
  font-size: 0.72rem;
  font-weight: 900;
  text-transform: uppercase;
}

select {
  min-height: 44px;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: rgba(8, 12, 11, 0.82);
  color: var(--paper);
  padding: 0 10px;
}

input[type="range"] {
  width: 100%;
  min-height: 44px;
  accent-color: var(--cyan);
}

.workbench-grid {
  display: grid;
  grid-template-columns: minmax(250px, 0.62fr) minmax(520px, 1.42fr) minmax(300px, 0.74fr);
  gap: 14px;
  align-items: start;
}

.candidate-panel,
.engine-panel,
.protocol-panel,
.falsify-panel,
.source-section {
  padding: 14px;
  min-width: 0;
}

.candidate-panel {
  position: sticky;
  top: 14px;
}

.panel-heading,
.mini-heading {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 10px;
  margin-bottom: 12px;
}

.panel-heading strong,
.mini-heading strong {
  font-size: 0.98rem;
  text-align: right;
}

.candidate-list,
.target-list,
.drug-list,
.protocol-list,
.audit-list {
  display: grid;
  gap: 9px;
}

.candidate-card {
  display: grid;
  gap: 7px;
  width: 100%;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 12px;
  background: rgba(11, 15, 14, 0.76);
  color: var(--paper);
  text-align: left;
  cursor: pointer;
}

.candidate-card.active {
  border-color: rgba(183, 255, 82, 0.72);
  background: rgba(183, 255, 82, 0.1);
}

.candidate-card strong {
  font-size: 0.96rem;
}

.candidate-card em {
  color: var(--paper-2);
  font-size: 0.84rem;
  font-style: normal;
  line-height: 1.42;
}

.selected-brief {
  margin-top: 12px;
  border-top: 1px solid var(--line);
  padding-top: 12px;
}

.selected-brief ul,
.protocol-grid ul,
.falsify-card ul {
  margin: 8px 0 0;
  padding-left: 18px;
}

.mechanism-map {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 8px;
}

.mechanism-node,
.ranking-panel,
.protocol-grid article,
.protocol-list article,
.study-sketch,
.falsify-card,
.receipt-grid article {
  border: 1px solid var(--line);
  border-radius: 8px;
  background: rgba(10, 14, 13, 0.7);
  padding: 12px;
}

.mechanism-node {
  min-height: 150px;
}

.mechanism-node strong {
  display: block;
  margin: 8px 0 6px;
}

.mechanism-node span {
  color: var(--coral);
  font-family: var(--font-mono);
  font-size: 0.78rem;
  font-weight: 850;
}

.dual-output-grid {
  display: grid;
  grid-template-columns: 1fr 0.82fr;
  gap: 10px;
  margin-top: 12px;
}

.target-row {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 92px;
  gap: 10px;
  align-items: center;
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 11px;
  background: rgba(239, 245, 224, 0.045);
}

.target-row em {
  grid-column: 1 / -1;
  font-size: 0.82rem;
  font-style: normal;
}

meter {
  width: 88px;
  height: 12px;
  accent-color: var(--lime);
}

.drug-card {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 11px;
  background: rgba(239, 245, 224, 0.045);
}

.drug-card--warning {
  border-color: rgba(255, 118, 101, 0.5);
}

.score-line {
  width: 100%;
  height: 7px;
  overflow: hidden;
  border-radius: 999px;
  background: rgba(239, 245, 224, 0.12);
}

.score-line progress {
  display: block;
  width: 100%;
  height: 100%;
  overflow: hidden;
  border: 0;
  border-radius: inherit;
  appearance: none;
  -webkit-appearance: none;
  background: transparent;
}

.score-line progress::-webkit-progress-bar {
  border-radius: inherit;
  background: transparent;
}

.score-line progress::-webkit-progress-value {
  border-radius: inherit;
  background: linear-gradient(90deg, var(--cyan), var(--lime));
}

.score-line progress::-moz-progress-bar {
  border-radius: inherit;
  background: linear-gradient(90deg, var(--cyan), var(--lime));
}

.protocol-panel {
  grid-column: 2 / 3;
}

.protocol-grid,
.receipt-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 10px;
}

.protocol-list {
  margin-top: 10px;
}

.protocol-list strong {
  display: block;
  margin-bottom: 6px;
}

.protocol-list em {
  display: block;
  margin-top: 8px;
  font-size: 0.86rem;
  font-style: normal;
}

.study-sketch {
  margin-top: 10px;
}

.falsify-panel {
  display: grid;
  gap: 10px;
  grid-column: 3 / 4;
  grid-row: 1 / span 2;
}

.falsify-card > span {
  color: var(--coral);
}

.audit-card {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 10px;
  background: rgba(239, 245, 224, 0.045);
}

.audit-card span {
  color: var(--muted);
  font-size: 0.68rem;
  font-weight: 950;
  text-transform: uppercase;
}

.audit-card--ok {
  border-color: rgba(88, 220, 205, 0.45);
}

.audit-card--fail {
  border-color: rgba(255, 118, 101, 0.65);
}

.source-section {
  margin-top: 14px;
}

.source-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 9px;
}

.source-grid a {
  display: grid;
  gap: 7px;
  background: rgba(9, 13, 12, 0.68);
}

.source-grid strong {
  color: var(--paper);
  font-size: 0.9rem;
}

.receipt-grid {
  grid-template-columns: repeat(3, minmax(0, 1fr));
  margin-top: 10px;
}

code {
  display: block;
  margin: 8px 0;
  overflow-wrap: anywhere;
  color: var(--cyan);
  font-family: var(--font-mono);
  font-size: 0.78rem;
}

.empty-note {
  margin: 0;
  color: var(--paper-2);
}

@media (max-width: 1180px) {
  .control-grid,
  .workbench-grid,
  .source-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .candidate-panel,
  .protocol-panel,
  .falsify-panel {
    position: static;
    grid-column: auto;
    grid-row: auto;
  }

  .engine-panel {
    grid-column: 1 / -1;
  }
}

@media (max-width: 820px) {
  .disease-lab-shell {
    padding-inline: 10px;
  }

  .lab-focus-strip,
  .hero-grid,
  .control-grid,
  .workbench-grid,
  .mechanism-map,
  .dual-output-grid,
  .protocol-grid,
  .source-grid,
  .receipt-grid {
    grid-template-columns: 1fr;
  }

  .lab-topbar,
  .panel-heading,
  .mini-heading {
    align-items: flex-start;
  }

  .lab-topbar[data-site-header] .site-secondary-links[data-disease-section-nav] {
    flex-wrap: nowrap;
    justify-content: flex-start;
  }

  .lab-focus-strip {
    gap: 8px;
    padding: 10px 12px;
  }

  h1 {
    margin-bottom: 8px;
  }

  .hero-proof div {
    padding: 10px;
  }

  .hero-copy {
    min-height: 0;
  }

  .mechanism-node {
    min-height: 0;
  }

  .target-row {
    grid-template-columns: 1fr;
  }

  meter {
    width: 100%;
  }
}

@media (prefers-reduced-motion: reduce) {
  *,
  *::before,
  *::after {
    scroll-behavior: auto !important;
  }
}